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Usually when you hit a Mario Question Mark Block, a coin comes out. Or a star. Or a flower. Or a leaf. Or a feather. Or a…OK, enough of that crap!
Basically, when you pound a Mario Question Mark Block with your fist, a fluffy snot rag like this doesn’t come out [via technabob]:

Shame, though! Tissues are useful. Especially if you’re this guy.
You can purchase this rare block from Etsy user lostmitten for 14 boogers.